Options
Structural-functional studies of chorismate synthase and glutamyl-tRNA synthetase from M. tuberculosis
Citation Link: https://doi.org/10.15480/882.421
Other Titles
Struktur-Funktionsstudien der Chorismat Synthase und Glutamyl-tRNA Synthetase aus M. tuberculosis
Publikationstyp
Doctoral Thesis
Publikationsdatum
2008
Sprache
English
Author
Advisor
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2007-11-02
Institut
A structural-functional analysis of the enzymes chorismate synthase and glutamyltRNA synthetase from Mycobacterium tuberculosis is presented. Crystal structures of both enzymes were solved using X-ray crystallography and a functional analysis showed how single amino acids strongly influence the enzymatic mechanism on a macroscopic level. The data provides a starting point for the design of novel antimycobacterial compounds.
Schlagworte
Roentgenkristallografie, Mykobacterium tuberculosis, Shikimat Biosynthese, tRNA Biosynthese, Enzymatische Reaktion
X-ray crystallography, Mycobacterium tuberculosis, Shikimate pathway, tRNA synthesis, enzymatic reaction
Loading...
Name
bruning_thesis_final_0808.pdf
Size
20.97 MB
Format
Adobe PDF